Neuroscience (Life Sciences) PhD – (Ph.D.)

PhD programmes are based on individual research projects that last 3 or 4 years, working with a specific academic supervisor (principle investigators). Applicants are specifically matched with a principle investigator based on their research interests and background.
Neuroscientists in the Faculty interact to deliver a wide range of projects focused on research into the cellular and molecular mechanisms of neuronal regulation and neurodegeneration in the CNS and PNS. A major focus is to understand processes of neurodegeneration in order to uncover aetiology and/or treat the common diseases of the nervous system, for example Alzheimers, Parkinsons disease and stroke. There are also several groups studying how the brain controls complex behaviours such as feeding and sleeping. In vivo and in vitro techniques are used and include primary neuronal cell culture, patch-clamp recording, ion flux Imaging, receptor binding assays and imaging of GFP- fusion proteins. There is a significant level of collaboration with clinicians and major links with large and small pharmaceutical companies. Drug discovery programmes and neuroscience- based spin out companies are being set up and encouraged through interaction with Manchester Biotech, which is ideally positioned adjacent to the Faculty. General areas of neuroscience research include:
The Basal Ganglia & Movement Disorders
Actions of Cytokines & Growth Factors in the Brain
Cell Biology of Neuronal Regulation & Neurodegeneration
Molecular Basis of Ion Channel Function
Peripheral & Diabetic Neuropathy
Comparative Neuroendocrinology
Neuronal Control of Biological Clocks
Regulation of Body Weight & Feeding